Have you ever noticed that your alertness might be a bit excessive? How do your stress levels compare to your hunger levels? If your answer is between “yes” and “I'm not sure,” it might be related to a particular hormone. A team recently argued that this culprit hormone can negatively impact sleep and delay feelings of fullness. Why does this matter? Sleep is crucial not only for recovering from the day's activities but also for glucose metabolism and overall metabolic function. As for food intake, a delay in satiety means individuals will feel hungry more frequently. This begs the question: What preventative measures can be taken to keep all weight-related factors aligned? This is where OrexiBurn comes in.
What is OrexiBurn?
OrexiBurn is an all-natural dietary supplement designed to support healthy metabolic function, boost energy and vitality, and, over time, promote desirable weight loss results. The creators clarified that they have taken a simple and non-stimulant approach to weight loss. However, their approach left our editorial team scratching their heads because it involves one of the most complex and possibly contradictory hormones. This hormone is believed to positively affect one set of weight loss factors while negatively impacting others. Could a hormone that positively impacts metabolism still find a way to increase appetite and counteract weight management? Stay tuned for the next section to find out.
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How does OrexiBurn work?
As hinted in the supplement's name, OrexiBurn is designed to support the orexin hormone. Orexins are potent neuropeptides associated with sleep, appetite, and stress. Primarily synthesized in the lateral hypothalamus, this peptide is said to act as a neurotransmitter that plays a fundamental role in regulating our sleep-wake cycles, promoting wakefulness, and inhibiting REM. Researchers explained that these peptides are highly active during wakefulness, promoting arousal and alertness while declining in concentration in REM sleep.
Interestingly, ever since its discovery, orexin has been known for its ability to regulate appetite. Specifically, this is achieved by increasing energy expenditure, thermogenesis (fat burning by increasing heat production), and fat metabolism. Furthermore, they are expressed predominantly in various tissues, including brown adipose tissues (good fat tissues) and skeletal muscles. Regarding blood glucose levels, orexin might interact with insulin-producing beta cells to trigger insulin release.
These factors might positively impact weight management despite their appetite-stimulating effects (i.e., delaying normal satiety sequence). Finally, orexin is believed to interact with leptin (or the satiety hormone) to further regulate feeding behavior and energy balance. Another interesting and important finding is the relationship between orexin and stress. The same source referenced a new study in which orexin's behavior was assessed in the presence of “habituation to repeated stress.”
In particular, researchers found that when orexin is used for a stress response, it will have a decreased reaction to it. So, orexin levels actually drop over a period of repeated stress by way of blocking one of two orexin receptors (i.e., orexin 2). Which is it? Is orexin good or bad? From the looks of things, orexin's mechanism is multi-faceted and complex, possibly having positive and negative effects.
At this point, it's too hard to choose sides. That said, looking into the ingredients might provide better insight into whether orexin's positives outweigh the negatives. Let's get right to it.
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What ingredients are in OrexiBurn?
The OrexiBurn formula is composed of the following ingredients:
L-Arginine (300 mg)
L-arginine is an amino acid, or protein building block, and a nitric oxide precursor (NO). Nitric oxide is a type of molecule that helps relax blood vessels and helps deliver oxygen to muscles, thereby lowering blood pressure and improving athletic performance. Interestingly, one study that looked at the effects of low-dose orexin in combination with L-arginine found that the duo might have antidepressant effects. Another study that looked specifically at the duo's impact on appetite found that orexin's typical role of increasing food intake decreased, concluding that “nitric oxide is a central regulator of food consumption,” affecting the brain's signaling pathways linked to hunger and satiety.
Citrus Bioflavonoid 50% (40 mg)
Citrus bioflavonoids are a class of flavonoid compounds derived from citrus fruits. This normally includes the likes of hesperidin, hesperetin, naringin, naringenin, diosmin, quercetin, rutin, and tangeretin, to name a few. In terms of their ability to attenuate metabolic syndrome, this class of compounds is believed to work by targeting oxidative stress, diabetes, fat metabolism, adipose tissue inflammation, and atherosclerosis.
These mechanisms are attributed to citrus bioflavonoids' antioxidant, anti-inflammatory, and cytoprotective properties by neutralizing free radicals. Regarding symptoms of diabetes, citrus bioflavonoids might improve “glucose tolerance, increase insulin secretion and sensitivity, decrease insulin resistance,” and many more.
Brown Seaweed Extract (30 mg)
Brown seaweed is one of three main types of phyla. Unlike the other two, this one contains a rich source of iodine and soluble fiber sources (e.g., alginate, fucoidan, and laminarin). To date, research has revealed several of its compounds' properties, which include antioxidant, anti-inflammatory, and anti-obesity effects, thereby easing and preventing the risk of increased inflammation, hypertension, and the development of diabetes.
One study of overweight or obese subjects looked at the effects of administering a 500 mg extract of either brown seaweed extract or a placebo in combination with a low-calorie diet. By the end of the intervention, the researchers confirmed that the consumption of brown seaweed extract had no effect on body weight or glucose levels. However, marginal changes in metabolic parameters were observed primarily due to its inflammatory response, possibly preventing the risk of type 2 diabetes.
Other possible mechanisms through which brown seaweed extract might induce weight loss results include increasing glucagon-like peptide-1 (GLP-1) protein levels, lowering appetite, maintaining post-meal glucose levels (by blocking SGLT1's role in transporting glucose into the small intestine), and improving mitochondrial function.
L-Ornithine Alpha-Ketoglutarate (30 mg)
Ornithine ketoglutarate (OKG), a salt made from the combination of ornithine and alpha-ketoglutarate, is a precursor to a nonessential amino acid called glutamine. Given the nature of this ingredient, individuals can anticipate an increase in protein synthesis and a boost to immune and digestive functions. Interestingly, this ingredient has also been demonstrated to increase insulin levels, ultimately regulating blood sugar levels.
As for another possible reason why this ingredient may have been selected for OrexiBurn, it has to do with its role. In particular, one review highlighted that alpha-ketoglutarate plays a crucial role in “cellular energy metabolism, amino acid/protein synthesis, epigenetic regulation, stemness, and differentiation,” thereby making it a fitting candidate for extending lifespan. Both orexin and OKG share energy metabolism. In particular, the former promotes energy use by activating brown adipose tissue, whereas the latter secretes growth hormones associated with energy metabolism.
Unfortunately, no evidence suggests that OKG stimulates orexin's effects or that the duo is synergistic in promoting weight management outcomes.
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Myrciaria Jabuticaba Skin Extract — Standardized to 25% Polyphenols (30 mg)
Jabuticaba fruit, also known as the Brazilian berry, is a fruit covered by a dark purple peel. The extract is made from the peel, which contains a rich source of bioactives called polyphenols. The latter suggests that this extract is rich in antioxidant activity, critical for neutralizing free radicals and their implications on overall wellness. Aside from its antioxidant activity, Jabuticaba peel has been shown to reduce blood cholesterol levels, insulin resistance, and blood pressure levels and exhibit vasodilation effects.
Phosphatidylserine 50% (10 mg)
Phosphatidylserine is a phospholipid that protects brain cells. This fatty substance transmits messages in the brain to help improve memory and cognitive function. This means a possible improvement in attention and the ability to focus, relief of stress, promotion of sleep, and ease of symptoms of depression and anxiety. In the context of stress relief, this ingredient might reduce the body's levels of the cortisol hormone, which in turn might prevent increases in blood glucose and blood pressure levels.
CELLg8® Turmeric Root Extract Powder 70% (5 mg)
CELLg8® is a liposomal delivery system used to increase nutrient absorption. In this respect, CELLg8® has been shown to help the body absorb curcumin at doses of as little as 0.25 mg, ultimately improving metabolic function in subjects with metabolic slowdown. Aside from liposomal delivery, curcumin is renowned for its anti-inflammatory properties and antioxidant activity, both of which are critical for eliminating oxidative stress. Interestingly, this ingredient has been shown to increase brain-derived neurotrophic factor (BDNF).
BDNF plays a critical role in helping brain neurons establish new connections, consequently improving memory and attention. How about weight management? Regarding weight loss, curcumin might reduce fat tissue growth, limit weight regain, and increase insulin sensitivity. Moreover, the same source referenced a review of 21 studies, where researchers have reported a reduction in weight, BMI, and waist circumference and an increase in adiponectin, a hormone responsible for regulating metabolic function.
Glucoraphanin 1% (5 mg)
Glucoraphanin is an inactive ingredient belonging to the glucosinolate family of plant compounds. When this ingredient interacts with myrosinase, it activates a sulfur-rich compound called sulforaphane. One source reported some health benefits of this ingredient, including its role in exhibiting antidiabetic effects. It might help transport sugar from the bloodstream into cells, muscles, and tissues. As such, individuals can anticipate reduced fasting blood sugar levels and improved hemoglobin A1C markers.
There is also some reason to believe that glucoraphanin might indirectly relieve constipation, but more research is still needed on this front.
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Frequently Asked Questions (FAQ)
Q: Is OrexiBurn safe?
A: According to the creators, OrexiBurn should be safe to take, as it contains all-natural ingredients that have been extensively studied and proven to be well-tolerated by most people. That said, this supplement is not meant for pregnant or nursing mothers and children under the age of 18. Individuals with a known medical condition might want to consult with a healthcare professional about the risks of medication interaction and/or side effects before adding anything new to an existing routine.
Q: Does OrexiBurn contain any allergens?
A: Based on the supplement's facts, OrexiBurn does not contain any of the common allergens. However, those with specific or rare allergic reactions may want to thoroughly investigate the ingredients before proceeding.
Q: How should OrexiBurn be taken?
A: For optimal results, individuals should either follow the label or the directions of a healthcare professional. The label suggests that adults should take no more than one OrexiBurn capsule daily with an adequate water source.
Q: What type of results can be expected from OrexiBurn?
A: Generally speaking, OrexiBurn might support metabolism, boost energy and vitality, and promote weight loss effects. Some specifics may include expanded blood vessels, insulin sensitivity, fat-burning, energy expenditure, and improved cognition, among a long list of therapeutic effects.
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Q: How long will it take for results to materialize with OrexiBurn?
A: Some people might see initial results in a week, while others may need months to see full results. Since time is undoubtedly required for optimal results, the creators recommend taking OrexiBurn for at most six months.
Q: How long will it take for OrexiBurn shipments to arrive?
A: Since this supplement is manufactured in the USA, domestic shipments should take up to 7 business days to arrive. In other circumstances, it could take around 15 business days.
Q: Does a money-back guarantee protect OrexiBurn?
A: Yes, OrexiBurn is protected by a 60-day money-back guarantee. This means that individuals are given a specific timeframe to try OrexiBurn. If the advertised benefits do not materialize, then the next best option is to initiate a request for a refund. The contact information is as follows:
- Email: contact@orexiburn-product.com.
- Return address: 285 Northeast Ave., Tallmadge, OH 44278, United States.
Ordering OrexiBurn
OrexiBurn is available online from the official website. The creators have reduced the per-bottle pricing to encourage long-term, consistent use. The below-listed rundown of prices best illustrates this:
- Order one bottle (1-month supply) for $69 each
- Order three bottles (3-month supply) for $59 each
- Order six bottles (6-month supply) for $49 each & get free shipping
Another added incentive of purchasing in bulk, specifically six bottles or more, is that individuals will be able to download the following digital resources once the payment has been processed:
- Bonus #1. Glow From Head to Toe: a guide on alleviating cellulite and boosting skin elasticity.
- Bonus #2. Sacred Tribal Wisdom: a guide on completely detoxing the body using no more than three ancient morning habits.
Final Verdict
From the entire review, individuals should have gathered that OrexiBurn aims to promote weight loss by offsetting some of the effects of the orexin hormone. While this hormone might improve markers of blood sugar (i.e., insulin secretion, insulin sensitivity, postmeal blood sugar levels, etc.), improve metabolism, and respond lightly to stress (once it has gotten used to its presence), research suggests that it might delay the effects of satiety, therefore increasing hunger signals. Will this supplement lower or accelerate the effects of orexin?
Our research suggests that only one of the several ingredients might have an effect on orexin, and that entails lowering the impact of orexin. The rest of the formula might increase antioxidant and anti-inflammatory effects, both of which help tame inflammation and oxidative stress. The latter duo is responsible for chronic health conditions, even metabolic syndrome. Speaking of the remainder of the formula, other mechanisms by which they might promote weight loss include the usual: curbing appetite, increasing energy expenditure, inducing thermogenesis, improving fat metabolism, and regulating blood sugar levels.
Our editorial team continues to be perplexed by the rationale behind selecting the orexin hormone as the target, particularly given its intricate nature and dual roles. Other than that, OrexiBurn might have the potential to pave the path for weight loss.