Sesame Care

Program Overview

Launched in August 2024, “Success by Sesame” is an online weight-loss program integrating medical supervision with pharmacological support. The program is designed to provide personalized care through virtual consultations, laboratory assessments, and, when appropriate, the administration of weight loss medications. A distinctive feature of this program is its inclusion of compounded semaglutide—a GLP-1 receptor agonist known for its efficacy in weight management—offered at cost without retail markup. This approach positions the program as a cost-effective alternative in the telehealth market.

Medical Foundation

The cornerstone of the “Success by Sesame” program is its utilization of GLP-1 receptor agonists, particularly semaglutide. Semaglutide functions by mimicking the incretin hormones that the body naturally produces to stimulate insulin secretion in response to meals. This mechanism not only aids in blood sugar regulation but also promotes satiety, leading to reduced caloric intake. Clinical trials have demonstrated the efficacy of semaglutide in facilitating significant weight loss among individuals with obesity or overweight conditions.

The program offers two primary subscription options:

1. Compounded Semaglutide Included: Priced at $249 per month, this option encompasses video consultations, necessary laboratory tests, unlimited messaging with healthcare providers, and four pre-measured injectable syringes of compounded semaglutide per month. The medication is supplied by a registered 503B pharmacy, ensuring compliance with compounding regulations. Notably, the program does not accept insurance for this option, but payments can be made via Health Savings Accounts (HSA), Flexible Spending Accounts (FSA), or credit cards.
2. Prescription Only: At $89 per month, this alternative includes the same clinical services—video consultations, lab tests, and unlimited provider messaging—but provides a prescription for brand-name GLP-1 medications such as Wegovy, Zepbound, or Saxenda, when deemed appropriate. The cost of these medications is not included, and patients are responsible for procuring them through their preferred pharmacies. This option is particularly suitable for individuals with insurance coverage for these medications, as the program offers assistance with insurance paperwork to help reduce medication costs.

Efficacy and Outcomes

The effectiveness of the “Success by Sesame” program is closely tied to the pharmacodynamics of semaglutide. Studies have indicated that semaglutide can lead to an average weight loss of approximately 15% of initial body weight over a 68-week period when combined with lifestyle interventions. Patients have reported experiencing reduced appetite and increased satiety, contributing to decreased caloric consumption and subsequent weight loss.

The program's structure, which includes regular virtual consultations and continuous provider support, is designed to enhance adherence to treatment protocols and promote sustainable lifestyle changes. The inclusion of unlimited messaging allows for real-time communication between patients and healthcare providers, facilitating timely adjustments to treatment plans and addressing patient concerns promptly.

Accessibility and Convenience

One of the program's strengths lies in its accessibility. By leveraging telehealth platforms, “Success by Sesame” eliminates geographical barriers, making weight loss support available to individuals across all 50 U.S. states. The convenience of home delivery for medications and the flexibility of scheduling virtual consultations cater to the needs of individuals with demanding lifestyles.

The program's transparent pricing model is another advantage. By offering compounded semaglutide at cost, Sesame Care distinguishes itself from competitors who may include retail markups. This pricing strategy not only makes the program more affordable but also reflects a commitment to patient-centered care.

Potential Limitations

While the “Success by Sesame” program offers a comprehensive approach to weight management, there are considerations to be mindful of:

• Medication Suitability: GLP-1 receptor agonists like semaglutide are not appropriate for everyone. Individuals with a history of pancreatitis, medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or those with Type 1 diabetes should avoid these medications. A thorough medical evaluation during the initial consultation is essential to determine suitability.
• Side Effects: Common side effects associated with semaglutide include nausea, vomiting, diarrhea, abdominal pain, and constipation. These adverse effects are typically transient but can impact patient adherence to the medication regimen.
• Insurance and Cost: While the program offers an option that includes medication, the $249 monthly fee may still be a financial consideration for some individuals, especially since insurance is not accepted for this option. Conversely, the $89 per month prescription-only option requires patients to have insurance coverage for the medications, which may not be feasible for everyone.
• State Restrictions: As of the latest updates, compounded semaglutide is not available through the program in Alabama, California, Louisiana, and Mississippi. Additionally, the cost of lab orders is not included in New York, New Jersey, or Rhode Island. Prospective participants from these states should consider these limitations when evaluating the program.

Comparative Perspective

In comparison to other telehealth weight loss programs, “Success by Sesame” is competitively priced. For instance, similar programs from providers like Ro and Hims & Hers are priced between $399 and $444 per month, making Sesame's $249 offering a more affordable alternative. The program's emphasis on personalized care, transparent pricing, and the inclusion of compounded semaglutide without retail markup further enhances its appeal in the weight management market.

Patient Experience and Testimonials

Anecdotal evidence from patient testimonials suggests that “Success by Sesame” has been well received by individuals looking for a medically guided weight loss program. Many patients appreciate the ease of access to board-certified healthcare providers, the affordability of compounded semaglutide, and the convenience of telehealth consultations.

Positive experiences often highlight:

• Convenience: Patients can engage in the program from the comfort of their homes without needing to visit a clinic or pharmacy regularly.
• Affordability: Compared to name-brand medications like Wegovy, which can cost upwards of $1,000 per month without insurance, the $249 option is significantly more budget-friendly.
• Supportive Provider Interaction: The unlimited messaging feature ensures that patients feel supported throughout their journey, allowing them to ask questions and make adjustments to their plan in real-time.

However, some patients report challenges, particularly with the availability of compounded semaglutide in certain states, occasional supply chain delays, and side effects common to GLP-1 receptor agonists.

Scientific Backing of GLP-1 Medications in Weight Loss

GLP-1 receptor agonists, particularly semaglutide, have a strong clinical backing in the realm of weight management. Numerous peer-reviewed studies have demonstrated their effectiveness in reducing body weight in patients with obesity or overweight conditions.

A landmark study published in the New England Journal of Medicine (Wilding et al., 2021) found that patients taking semaglutide 2.4 mg once weekly lost an average of 14.9% of their body weight over 68 weeks compared to the placebo group, which lost just 2.4%. Additionally, improvements in cardiometabolic markers such as blood pressure, HbA1c levels, and lipid profiles were observed.

Other research has also pointed to the sustainability of weight loss with GLP-1 therapy. A 2022 study in The Lancet Diabetes & Endocrinology found that continued use of semaglutide helped maintain weight loss and reduce the risk of weight regain, which is a common challenge in traditional diet and exercise-based interventions.

Given this extensive scientific support, “Success by Sesame” aligns with evidence-based medical approaches to obesity management, providing a structured way for individuals to achieve significant weight loss through proven pharmacological methods.

How It Compares to Traditional Weight Loss Methods

Traditional weight loss programs primarily focus on lifestyle modifications, including calorie restriction, increased physical activity, and behavioral counseling. While these interventions are effective, studies have shown that adherence can be challenging due to factors such as metabolic adaptation, hunger regulation, and psychological barriers.

In contrast, GLP-1 receptor agonists like semaglutide address weight loss at a physiological level by:

• Reducing Appetite: By slowing gastric emptying and enhancing satiety signals, patients feel full with smaller portions.
• Regulating Blood Sugar: By stabilizing blood glucose levels, patients experience fewer hunger spikes and cravings.
• Targeting Fat Loss Rather Than Lean Mass: Unlike drastic calorie-cutting diets, GLP-1-based therapies help preserve lean muscle while promoting fat loss.

While traditional weight loss methods remain important, medications like semaglutide offer a viable alternative for individuals who have struggled with sustained weight loss despite diet and exercise interventions.

The Role of Behavioral and Lifestyle Changes in the Program

Though “Success by Sesame” is centered around pharmacological intervention, it does not neglect the importance of behavioral and lifestyle modifications. Patients are encouraged to incorporate:

• Nutritional Adjustments: Emphasizing whole, nutrient-dense foods while reducing processed and calorie-dense meals.
• Physical Activity: While not mandatory, regular movement supports metabolic health and can enhance weight loss results.
• Cognitive and Behavioral Coaching: Patients receive guidance on breaking unhealthy eating patterns, developing sustainable habits, and improving their relationship with food.

The integration of these components ensures that weight loss is not solely dependent on medication but is complemented by holistic health improvements.

Regulatory Considerations and Safety

As with any telehealth weight loss program, regulatory compliance and patient safety are paramount. “Success by Sesame” adheres to telehealth guidelines by ensuring:

• Consultations with Licensed Healthcare Providers: Each patient undergoes an assessment before being prescribed medication.
• Strict Compliance with Pharmacy Regulations: The compounded semaglutide is sourced from a 503B pharmacy, which adheres to FDA compounding standards.
• Monitoring and Follow-Ups: Regular virtual check-ins allow healthcare providers to monitor patient progress and make necessary adjustments to treatment.

However, it is important for patients to conduct their due diligence and consult with their primary care provider before starting a GLP-1-based weight loss program, particularly if they have underlying health conditions.

Who Should Consider “Success by Sesame”?

This program may be a suitable option for individuals who:

• Have a BMI of 30 or higher (or a BMI of 27+ with weight-related conditions such as hypertension or diabetes).
• Have struggled with traditional weight loss methods and need additional medical support.
• Are looking for a cost-effective alternative to branded weight loss medications.
• Prefer the convenience of telehealth services over in-person clinical visits.

Conversely, individuals who should not enroll include:

• Those with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (due to potential thyroid cancer risks associated with GLP-1 receptor agonists).
• Individuals with pancreatitis or severe gastrointestinal disorders.
• Women who are pregnant or breastfeeding.
• Those who prefer non-medication-based weight loss strategies.

Final Verdict: Is “Success by Sesame” Worth It?

The “Success by Sesame” online weight loss program presents a compelling option for individuals seeking a medically guided and affordable approach to weight management. By offering compounded semaglutide at cost, providing personalized virtual care, and ensuring transparent pricing, Sesame Care has positioned itself as a leader in the telehealth weight loss space.

Key Takeaways:

Affordability: At $249 per month (including compounded semaglutide), the program is more cost-effective than many competitors.

Science-Backed Approach: Utilizes GLP-1 receptor agonists, which have demonstrated significant weight loss benefits in clinical trials.

Convenience: Fully online, making it accessible to individuals across the U.S.

Comprehensive Care: Includes virtual consultations, lab work, and ongoing provider support.

Potential Drawbacks:

• Availability Restrictions: Compounded semaglutide is not available in certain states.
• Side Effects: Some patients may experience nausea, digestive discomfort, or appetite suppression beyond expectations.
• Insurance Considerations: The program does not accept insurance for the $249 option, though HSA/FSA payments are allowed.

Overall, “Success by Sesame” is an excellent choice for those seeking a structured, evidence-based approach to weight loss. While it may not be a one-size-fits-all solution, it provides a valuable alternative for individuals who have struggled with weight management and are looking for an affordable and effective option in the evolving telehealth space.